Clear cell adenocarcinoma of the cervix, a rare entity of young females: A case report

DISCOVERIES (ISSN 2359-7232), 2025, volume 13, issue 1

_{ORIGINAL ARTICLE - Case Report}

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_{CITATION: Paul P, Pal PR, Hayat S. Clear cell adenocarcinoma of the cervix, a rare entity of young females: A case report. Discoveries 2025, 13(1): e205. DOI: 10.15190/d.2025.4}

_{Clear cell adenocarcinoma of the cervix, a rare entity of young females: A case report}

Paramita Paul ¹, Paramita Rudra Pal ^1, *, Sadaf Hayat ¹

• ¹ Department of Oncopathology; Homi Bhabha Cancer Hospital & Mahamana Pandit Madan Mohan Malviya Cancer Centre (Tata Memorial Centre); Homi Bhabha National Institute (HBNI), Varanasi, Uttar Pradesh-221005, India

 * Corresponding author: Paramita Rudra Pal, Department of Oncopathology; Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malviya Cancer Centre (Tata Memorial Centre); Homi Bhabha National Institute (HBNI), Varanasi, Uttar Pradesh-221005, India; Phone +91-7627948180; Email: drparamita14@gmail.com

_Abstract

Clear cell adenocarcinoma of the cervix is a rare neoplasm that accounts for about 4-9% of all uterine cervical adenocarcinoma. It was first reported in young women with in-utero exposure of diethylstilbesterol (DES). However, many cases have been reported post-ban of DES that are not associated with diethylstilbesterol (DES). Here, we are reporting a case of clear cell adenocarcinoma in an 18-year-old woman without any exposure history of DES. An exophytic mass arising from the anterior lip was found in MRI. Biopsy from the mass was diagnosed as Clear cell adenocarcinoma of the cervix based on histopathological and immunohistochemical findings. The patient then underwent a total hysterectomy and bilateral salpingo-oophorectomy. One each of the right pelvic lymph nodes and external iliac lymph nodes showed metastatic deposits. The patient was staged as FIGO stage I [AJCC TNM staging (8th Edition): pT2b pN1]. Post 6 months follow up there is no evidence of any recurrence.

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REFERENCES

_{1. Reich O, Tamussino K, Lahousen M, Pickel H, Haas J, Winter R. Clear cell carcinoma of the uterine cervix: pathology and prognosis in surgically treated stage IB-IIB disease in women not exposed in utero to diethylstilbestrol. Gynecol Oncol. 2000 Mar;76(3):331-5.}

_{2.     Bujor IE, Lozneanu L, Ursache A, Cristofor A, Scurtu AM, Plamadeala P, Gireada R, Mandici CE, Găină MA, Matasariu DR. Primary Clear Cell Adenocarcinoma of the Uterine Cervix in a 14-Year-Old Virgin Girl: Case Report. Int J Environ Res Public Health. 2022 Dec 11;19(24).}

_{3.     Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med. 1971 Apr 22;284(15):878-81.} 

_{4.     Teixeira JC, Santos DZ, Campos CS, Vale DB, Bragança JF, Zeferino LC. Cervical cancer in women under 25 years of age and outside the screening age: Diagnosis profile and long-term outcomes. Int J Gynaecol Obstet. 2021 Jul;154(1):150-156.}

_{5.     Liu Y, Shi X, Yang J, Zhou H, Peng P, Cao D. Clinical Features and Prognostic Factors of Cervical Clear Cell Adenocarcinoma: A Retrospective Analysis of 74 Cases from a Tertiary Hospital. Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338221149297.} 

_{6.     Hanselaar A., Van Loosbroek M., Schuurbiers O., Helmerhorst T., Bulten J., Bernhelm J. Clear cell adenocarcinoma of the vagina and cervix. An update of the Central Netherlands Registry showing twin age incidence peaks. Cancer. 1997;79: 2229–2236.}

_{7.     Jiang X, Jin Y, Li Y, Huang HF, Wu M, Shen K, Pan LY. Clear cell carcinoma of the uterine cervix: clinical characteristics and feasibility of fertility-preserving treatment. Onco Targets Ther. 2014 Jan 9;7:111-6. doi: 10.2147/OTT.S53204.}

_{8.     Yang L, Zheng A, Zhang X, Fang X, Sun W, Chen Y. Clear Cell Carcinoma of the Uterine Cervix: A Clinical and Pathological Analysis of 47 Patients Without Intrauterine Diethylstilbestrol Exposure. Int J Gynecol Cancer. 2017 Jun;27(5):1009-1014.}

_{9.     Hasegawa K, Nagao S, Yasuda M, Millan D, Viswanathan AN, Glasspool RM, et al. Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the uterine corpus and cervix. Int J Gynecol Cancer. 2014 Nov;24(9 Suppl 3):S90-5.}

_{10.     Stolnicu S, Karpathiou G, Guerra E, Mateoiu C, Reques A, Garcia A, Bart J, Felix A, Fanni D, Gama J, Hardisson D, Bennett JA, Parra-Herran C, Oliva E, Abu-Rustum N, Soslow RA, Park KJ. Clear Cell Carcinoma (CCC) of the Cervix Is a Human Papillomavirus (HPV)- independent ¬¬Tumor Associated With Poor Outcome: A Comprehensive Analysis of 58 Cases. Am J Surg Pathol. 2022 Jun 01;46(6):765-773.}

_{11.     Liu Z, Li J, Gu H, Tu H, Liu G, Liu J. Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience. Front Oncol. 2020;10:532748}